Methadone is a medication approved by the Food and Drug Administration (FDA) to treat opioid use disorder (OUD) as a medication-assisted treatment (MAT), as well as for pain management. Methadone helps individuals achieve and sustain recovery from substance use disorder and reclaim active and meaningful lives. When taken as prescribed, methadone is safe and effective. Methadone, a long-acting opioid agonist, reduces opioid craving and withdrawal and blunts or blocks the effects of opioids. Methadone, taken daily, is available in liquid, powder, and diskette forms.